MK-677
Management of muscle-wasting conditions
Potential therapy for osteoporosis and bone density improvement
Investigation into anti-aging and metabolic health applications
MK-677, also known as Ibutamoren, is an orally active, non-peptide growth hormone secretagogue. It mimics the action of ghrelin, stimulating the release of growth hormone (GH) and insulin-like growth factor 1 (IGF-1). Originally developed for treating growth hormone deficiencies and muscle-wasting conditions, it has gained attention for potential applications in anti-aging, performance enhancement, and metabolic health.
Mechanism of action
MK-677 binds to the ghrelin receptor (GHSR) in the brain, stimulating the pituitary gland to release GH. This leads to increased levels of IGF-1. Unlike exogenous GH administration, MK-677 stimulates endogenous GH release, potentially preserving natural hormone rhythms.
Notable Studies
A study in healthy older adults showed that MK-677 counteracted factors contributing to sarcopenia, including reduced GH secretion and loss of fat-free mass.
Clinical trials have demonstrated that MK-677 increases serum IGF-1 levels and markers of bone formation, suggesting potential benefits for bone health.
Risk Associated
Increased appetite
Water retention and edema
Joint pain and muscle stiffness
Insulin resistance and elevated blood glucose levels
Dosage
In clinical studies, dosages of 10–25 mg per day have been used, with 25 mg being common for muscle growth and fat loss. It is typically taken once daily, preferably in the evening to align with natural GH secretion patterns.
External link
MK-677
Management of muscle-wasting conditions
Potential therapy for osteoporosis and bone density improvement
Investigation into anti-aging and metabolic health applications
Mechanism of action
MK-677 binds to the ghrelin receptor (GHSR) in the brain, stimulating the pituitary gland to release GH. This leads to increased levels of IGF-1. Unlike exogenous GH administration, MK-677 stimulates endogenous GH release, potentially preserving natural hormone rhythms.
Risk
Associated
Increased appetite
Water retention and edema
Joint pain and muscle stiffness
Insulin resistance and elevated blood glucose levels
Notable Studies
A study in healthy older adults showed that MK-677 counteracted factors contributing to sarcopenia, including reduced GH secretion and loss of fat-free mass.
Clinical trials have demonstrated that MK-677 increases serum IGF-1 levels and markers of bone formation, suggesting potential benefits for bone health.
Dosage
In clinical studies, dosages of 10–25 mg per day have been used, with 25 mg being common for muscle growth and fat loss. It is typically taken once daily, preferably in the evening to align with natural GH secretion patterns.
External link
MK-677
Management of muscle-wasting conditions
Potential therapy for osteoporosis and bone density improvement
Investigation into anti-aging and metabolic health applications
Mechanism of action
MK-677 binds to the ghrelin receptor (GHSR) in the brain, stimulating the pituitary gland to release GH. This leads to increased levels of IGF-1. Unlike exogenous GH administration, MK-677 stimulates endogenous GH release, potentially preserving natural hormone rhythms.
Risk
Associated
Increased appetite
Water retention and edema
Joint pain and muscle stiffness
Insulin resistance and elevated blood glucose levels
Notable Studies
A study in healthy older adults showed that MK-677 counteracted factors contributing to sarcopenia, including reduced GH secretion and loss of fat-free mass.
Clinical trials have demonstrated that MK-677 increases serum IGF-1 levels and markers of bone formation, suggesting potential benefits for bone health.
Dosage
In clinical studies, dosages of 10–25 mg per day have been used, with 25 mg being common for muscle growth and fat loss. It is typically taken once daily, preferably in the evening to align with natural GH secretion patterns.
External link
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Ibutamoren – Wikipedia
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Effects of an Oral Ghrelin Mimetic on Body Composition and Clinical Outcomes in Healthy Older Adults
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Oral Administration of the Growth Hormone Secretagogue MK-677 Increases Markers of Bone Turnover in Healthy and Functionally Impaired Elderly Adults
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MK-677 Dosage: How & When to Take It {& Best Cycle Length}
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MK-677 Side Effects: What You Should Know