GHK-Cu
Wound healing and tissue repair
Hair growth stimulation
Anti-inflammatory therapies
Antioxidant applications
GHK-Cu is a naturally occurring copper-binding tripeptide (glycyl-L-histidyl-L-lysine) found in human plasma, saliva, and urine. It plays a significant role in tissue repair, skin regeneration, and anti-inflammatory processes.
Mechanism of action
GHK-Cu functions by modulating gene expression, promoting the synthesis of collagen, elastin, and glycosaminoglycans. It also stimulates angiogenesis and exhibits antioxidant properties, contributing to tissue remodeling and repair.
Notable Studies
Research indicates that GHK-Cu enhances wound healing and skin regeneration by increasing collagen and glycosaminoglycan production.
Studies have demonstrated its ability to improve skin elasticity, reduce wrinkles, and promote hair growth.
GHK-Cu has shown potential in reducing inflammation and oxidative stress in various tissues.
Risk Associated
While GHK-Cu is generally well-tolerated, potential side effects may include:
Skin irritation or redness at the application site
Allergic reactions in sensitive individuals
Unknown long-term effects with prolonged use
Dosage
Topical application: Concentrations of 2-4% applied once or twice daily.
Injectable form: 1-2 mg administered subcutaneously daily, typically for five days a week.
External link
GHK-Cu
Wound healing and tissue repair
Hair growth stimulation
Anti-inflammatory therapies
Antioxidant applications
Mechanism of action
GHK-Cu functions by modulating gene expression, promoting the synthesis of collagen, elastin, and glycosaminoglycans. It also stimulates angiogenesis and exhibits antioxidant properties, contributing to tissue remodeling and repair.
Risk
Associated
While GHK-Cu is generally well-tolerated, potential side effects may include:
Skin irritation or redness at the application site
Allergic reactions in sensitive individuals
Unknown long-term effects with prolonged use
Notable Studies
Research indicates that GHK-Cu enhances wound healing and skin regeneration by increasing collagen and glycosaminoglycan production.
Studies have demonstrated its ability to improve skin elasticity, reduce wrinkles, and promote hair growth.
GHK-Cu has shown potential in reducing inflammation and oxidative stress in various tissues.
Dosage
Topical application: Concentrations of 2-4% applied once or twice daily.
Injectable form: 1-2 mg administered subcutaneously daily, typically for five days a week.
External link
GHK-Cu
Wound healing and tissue repair
Hair growth stimulation
Anti-inflammatory therapies
Antioxidant applications
Mechanism of action
GHK-Cu functions by modulating gene expression, promoting the synthesis of collagen, elastin, and glycosaminoglycans. It also stimulates angiogenesis and exhibits antioxidant properties, contributing to tissue remodeling and repair.
Risk
Associated
While GHK-Cu is generally well-tolerated, potential side effects may include:
Skin irritation or redness at the application site
Allergic reactions in sensitive individuals
Unknown long-term effects with prolonged use
Notable Studies
Research indicates that GHK-Cu enhances wound healing and skin regeneration by increasing collagen and glycosaminoglycan production.
Studies have demonstrated its ability to improve skin elasticity, reduce wrinkles, and promote hair growth.
GHK-Cu has shown potential in reducing inflammation and oxidative stress in various tissues.
Dosage
Topical application: Concentrations of 2-4% applied once or twice daily.
Injectable form: 1-2 mg administered subcutaneously daily, typically for five days a week.
External link
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Pickart, L. et al. (2018). Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. International Journal of Molecular Sciences, 19(7), 1987.
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Pickart, L. et al. (2015). GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration. BioMed Research International, 2015, 648108.
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Margolina, A. (2023). Anti-aging activity of the GHK peptide – the skin and beyond. Skin Biology.
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Neurogan Health. (2023). GHK-Cu Peptide Dosage | How to Use Copper Peptides, Injections.
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Happy Hormones MD. (2024). GHK-Cu Patient Information.
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Neurogan Health. (2025). GHK-Cu Peptide Side Effects | Safety, Treatments.
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Peptide Sciences. (n.d.). What is GHK-Cu (Copper Peptide) and How Does it Work?
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Oncotarget. (2016). The tri-peptide GHK-Cu complex ameliorates lipopolysaccharide-induced acute lung injury in mice.
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ResearchGate. (2024). Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data.
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Peptides.org. (2023). GHK-Cu Side Effects, Complications, and Risk Profile.